|Title:||Adherence to Treatment by Initial Antihypertensive Mono and Combination Therapies|
|Date:||Wednesday 21st July 2021|
|Author(s) :||Rea, F.; SavarÃ©, L; Franchi, M.; Corrao, G; Mancia, G|
Aim of our study was to compare adherence to antihypertensive drug
therapy between newly treated patients in whom monotherapy or a
2-drug single-pill combination (SPC) was initially dispensed.
The 63,448 residents of Lombardy Region (Italy), aged 40–80 years,
who were newly treated with antihypertensive drugs during 2016,
were identified and followed for 1 year after the first prescription. The
outcome of interest was adherence to drug therapy that was measured
according to the "proportion of days covered" (PDC) criterion, i.e.,
the ratio between the number of days in which the drug was available
and the days of follow-up. Patients who had a PDC >75% and
<25% were defined as highly and poorly adherent to drug therapy,
respectively. Log-binomial regression models were fitted to compare
the propensity to treatment adherence between the initial therapeutic
strategies, after adjusting for baseline demographic and clinical
About 46% and 17% of patients showed high and poor adherence, respectively.
Compared with patients under initial monotherapy (85%),
those who were initially treated with a SPC (15%) had higher propensity
to be highly adherent and a lower propensity to be poorly adherent
to antihypertensive treatment (risk ratio: 1.18, 95% confidence interval
1.16–1.21; 0.42, 0.39–0.45, respectively). This was the case regardless the
sex, the age, the patient clinical status, and with almost any type of SPC.
In a real-life setting, patients who were initially prescribed a 2-drug
SPC exhibited more frequently a good adherence to antihypertensive
treatment than those starting with a single drug.
Author Laura SavarÃ¨ is currently affiliated to MOX-Politecnico di Milano|
This report, or a modified version of it, has been also submitted to, or published on
Federico Rea, Laura SavarÃ©, Matteo Franchi, Giovanni Corrao, Giuseppe Mancia, Adherence to Treatment by Initial Antihypertensive Mono and Combination Therapies, American Journal of Hypertension, 2021;, hpab083, https://doi.org/10.1093/ajh/hpab083